David Townson, Ph.D.
Kendall Hall, Room 509
Ph.D., Ohio State University, 1993
M.S., University of Wisconsin at Madison, 1988
B.S., Michigan State University, 1984
Principles of Biology I (BIOL 411); Contemporary Trends in Reproductive Physiology (ANSC 909); Special Topics: Designer Babies/Designer Cells - New Frontiers in Biotechnology (BIOL 401)
General Area of Interest and/or Specialty:
Female reproductive physiology; immunology of ovarian function; follicular dynamics; regulation of the corpus luteum
Description of Current Research and/or Professional Activities:
The current research in my laboratory focuses on the relationships between the immune system and the reproductive system in regard to ovarian function. Specifically, we are interested in how the local elaboration of leukocyte-specific chemotactic molecules facilitates leukocyte recruitment and impacts aspects of ovarian function, including follicular growth and atresia, ovulation, and the function of the corpus luteum.
Utilizing techniques of ultrasonography, immunohistochemistry, cell culture, and molecular biology, the regulation of immune response is being investigated under conditions of natural and experimentally-controlled ovarian function. We are also engaged in studies examining the effects of environmental stress on fertility in cattle, and the influence of physical stress on immune response in rats.
Sullivan, B.T., Cherry, J.A., Sakamoto, H., Henkes, L.E., Townson, D.H, Rueda, B.R. 2010 Cytokeratin-18 (CK18) expression inhibits cytokine-induced death of cervical cancer cells. International Journal of Gynecologic Cancer 20:1474-1481
Kneebone, J., Tsang, P.C.W, Townson, D.H. 2010 Short Communication: Rapid antibiotic screening tests detect antibiotic residues in powdered milk products. Journal of Dairy Science 93:3961-3964.
Townson, D.H., Putnam, A.N., Sullivan, B.T., Guo L., Irving-Rodgers, H.F. 2010 Expression and distribution of cytokeratin 8/18 intermediate filaments in bovine antral follicles and corpus luteum: An intrinsic mechanism of resistance to apoptosis? Histology and Histopathology 25: 889-900.
Cherry, J.A., Hou, X., Rueda, B., Davis J.S., Townson, D.H. Microvascular endothelial cells of the bovine corpus luteum: A comparative examination of the estrous cycle and pregnancy. J. Reprod Dev 54:183-191 (2008).
Townson, D.H. Immune cell-endothelial cell interactions in the bovine corpus luteum. Integr Comp Biol 46:1055-1059 (2006).
Liptak A.R., ,Sullivan, B.T., Henkes, L.E., Wijayagunawardane, M.P.B., Miyamoto, A., Davis, J.S., Rueda, B.R., Townson, D.H. Cooperative expression of monocyte chemoatractant protein 1 within the bovine corpus luteum: Evidence of immune cell-endothelial cell interactions in a coculture system. Biol Reprod 72: 1169-1176 (2005).
Townson, D.H., Tsang PCW, Butler WR, Frajblat M, Griel Jr. LC, Johnson CJ, Milvae RA, Niksic GM, Pate JL. Relationship of fertility to ovarian follicular waves before breeding in dairy cows. Cooperative Regional Research Project, NE-161. Journal of Animal Science 80:1053-1058 (2002).
Townson, D.H., O’Connor CL, Pru JK. Expression of monocyte chemoattractant protein-1 and the distribution of immune cell populations in the bovine corpus luteum throughout the estrous cycle. Biol Reprod 66:361-366 (2002).